A kwadoro Pembrolizumab na China maka HCC a na-apụghị ịgbasa na njikọta ya na Lenvatinib na TACE

N'oge na-adịbeghị anya, Merck & Co., Inc. (Merck) kwupụtara na National Medical Products Administration (NMPA) nke China akwadola ọgwụ mgbochi PD-1 ya, pembrolizumab, maka ojiji ya na lenvatinib na transarterial chemoembolization (TACE) maka ọgwụgwọ nke ndị ọrịa nwere ọrịa kansa hepatocellular nke a na-apụghị ịgbanahụ, nke na-abụghị nke metastatic.

Nkwenye nke ihe ngosi ọhụrụ a dabere na data sitere na nnwale ahụike nke Phase III LEAP-012. N'ọmụmụ ihe Phase III a nke ọtụtụ etiti, nke a na-enweghị usoro, nke a na-ahụ maka ihu abụọ (LEAP-012), e debanyere aha ndị ọrịa 480 ma kenye ha n'enweghị usoro ka ha nata lenvatinib tinyere TACE gbakwunyere pembrolizumab (n=237) ma ọ bụ TACE gbakwunyere placebo abụọ (n=243).

Nsonaazụ gosiri na ọnụọgụ ndụ nke na-enweghị ọganihu (PFS) dị ọnwa 14.6 n'ime otu lenvatinib tinyere TACE na pembrolizumab, ma e jiri ya tụnyere ọnwa 10.0 n'ime otu placebo. Ọnụọgụ ndụ nke ọnwa 24 (OS) bụ 75% na 69%, n'otu n'otu.

Lenvatinibbụ ihe mgbochi kinase nke a na-eji agwọ ụfọdụ ụdị ọrịa kansa. Ihe mgbochi kinase bụ ihe mgbochi enzyme nke na-egbochi ọrụ nke otu ma ọ bụ karịa protein kinases.

Pembrolizumab bụ ọgwụ mgbochi kappa monoclonal IgG4 nke a na-eduzi megide elu mkpụrụ ndụ mmadụ PD-1 (onye nnata ọnwụ-1 nke a na-ahazi) na lymphocytes. Onye nnata PD-1 na-enye "ihe nlele mgbochi ahụ," nke na-enyere aka igbochi sistemu ahụ ji alụso ọrịa ọgụ ịwakpo onwe ya. Ụdị etuto ụfọdụ nwere nnukwu ngosipụta nke PD-L1 (onye nnata ọnwụ nke a na-ahazi ligand-1). Ụdị etuto ndị ọzọ na-eji ike mgbochi ahụ ike na-agbanwe agbanwe ebe ha na-ewere physiology eke nke PD-L1 induction (nchedo nke mmebi ahụ ji alụso ọrịa ọgụ site na ọrịa) ma gbanwee ya gaa na nzaghachi mgbochi-tumor. Mgbe PD-L1 na-etinye aka na PD-1, ọrụ mkpụrụ ndụ T na-akwụsị; pembrolizumab na-egbochi nhazi mgbagwoju anya PD-1: PDL-1 nke na-enye ohere ka mma igbu mkpụrụ ndụ T.

Ugbu a, enwere ọtụtụ nnwale ahụike nke teknụzụ ọhụrụ na-egbochi kansa na China na-achọ ndị ọrịa. Maka ndụmọdụ gbasara ọgwụ na teknụzụ ọhụrụ, ị nwere ike ịkpọtụrụ Ngalaba Mba Nile nke Ụlọ Ọgwụ Oncology nke Beijing South Region.

Nọmba ekwentị: 4008803716

Email：myimmnet@163.com