Na Ọgọst 22, 2025, Datopotamab deruxtecan (Dato-DXd; Datroway) enwetala nkwado na China maka ọgwụgwọ nke ndị okenye nwere kansa ara HER2-negative (immunohistochemistry [IHC] 0, IHC 1+, ma ọ bụ IHC 2+/in situ hybridization [ISH] negative) ndị natara ọgwụgwọ endocrine na opekata mpe otu usoro chemotherapy n'ọnọdụ dị elu.
Ugbu a, enwere ọtụtụ nnwale ahụike nke teknụzụ ọhụrụ na-egbochi kansa na China na-achọ ndị ọrịa. Maka ndụmọdụ gbasara ọgwụ na teknụzụ ọhụrụ, ị nwere ike ịkpọtụrụ Ngalaba Mba Nile nke Ụlọ Ọgwụ Oncology nke Beijing South Region.
Nọmba ekwentị: 4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Nkwenye a dabere na nsonaazụ dị mma nke ọmụmụ TROPION-Breast01 zuru ụwa ọnụ. Ọmụmụ TROPION-Breast01 zuru ụwa ọnụ, nke 3, nke mepere emepe, nke a na-enweghị usoro nyocha lere anya na trophoblast cell surface antibody-drug conjugate datopotamab deruxtecan (Dato-DXd) na nhọrọ nke onye nyocha nke chemotherapy (ICC) na hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+/HER2-) kansa ara.
E kenyere ndị ọrịa na Dato-DXd (n = 365) ma ọ bụ ICC (n = 367). Dato-DXd belatara nke ukwuu ihe ize ndụ nke ọganihu ma ọ bụ ọnwụ ma e jiri ya tụnyere ICC (PFS site na oke ihe ize ndụ BICR [HR], 0.63 [95% CI, 0.52 ruo 0.76]; P < .0001). A hụrụ uru PFS na-adịgide adịgide n'ofe obere ndị otu. Ọ bụ ezie na data OS ezughị oke, a hụrụ usoro na-akwado Dato-DXd (HR, 0.84 [95% CI, 0.62 ruo 1.14]). Ọnụego nke ihe omume ọjọọ metụtara ọgwụgwọ ọkwa ≥3 (TRAEs) na Dato-DXd dị ala karịa ICC (20.8% v 44.7%). Ndị TRAE kachasị (ọkwa ọ bụla; ọkwa ≥3) bụ ọgbụgbọ (51.1%; 1.4%) na stomatitis (50%; 6.4%) na Dato-DXd na neutropenia (okwu otu, 42.5%; 30.8%) na ICC.
Ndị ọrịa natara Dato-DXd nwere mmụba dị ukwuu na nke bara uru n'ihe gbasara ahụike na PFS yana profaịlụ nchekwa dị mma ma dịkwa mma, ma e jiri ya tụnyere ICC.
Ugbu a, enwere ọtụtụ nnwale ahụike nke teknụzụ ọhụrụ na-egbochi kansa na China na-achọ ndị ọrịa. Maka ndụmọdụ gbasara ọgwụ na teknụzụ ọhụrụ, ị nwere ike ịkpọtụrụ Ngalaba Mba Nile nke Ụlọ Ọgwụ Oncology nke Beijing South Region.
Nọmba ekwentị: 4008803716
WeChat ID: 17801183037
Email：myimmnet@163.com
Oge ozi: Ọgọst-26-2025